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I&D: How to Perform an Incision & Drainage

William Kelly, MSN, FNP-C
Updated June 2026 · Medically reviewed for nurses
13 min read

An I&D (Incision & Drainage) treats infections that have turned into abscesses. Knowing how to perform one is important for a nurse practitioner in most settings — especially the ER or urgent care.

This guide covers when an I&D is (and isn't) indicated, the role of antibiotics including MRSA coverage and endocarditis prophylaxis, and the full step-by-step procedure for draining an abscess.

What Is an I&D?

An Incision & Drainage is performed when fluid accumulates in the body and needs to be drained — usually from a skin abscess. It's done in urgent cares, emergency departments, or outpatient clinics like general surgery. Patients typically complain of pain, swelling, and redness of the affected area.

Common abscess locations
Common Locations
Axillae (armpits), upper legs and buttock, the pilonidal region (above the buttcrack), and fingertips next to the nail (paronychia).
Risk factors
Who's at Risk
Anyone can get an abscess, but they're more common with poor hygiene, immunocompromise, diabetes, and obesity.

When to Do an I&D

An I&D drains purulent fluid (pus) from an abscess — the best way to treat the infection and prevent it from enlarging into something more serious. If no fluctuance is palpated (no fluid felt under the skin), a trial of PO antibiotics can likely be used instead. Most obvious abscesses, though, benefit from an I&D.

Refer These to a Surgeon

Some abscesses need surgical expertise: perirectal/perianal, anterior and lateral neck, hand abscesses (except paronychia), those adjacent to vital nerves or vessels, central facial abscesses, and breast abscesses near the areola/nipple. Abscesses >5 cm are also best drained and managed by a surgeon.

I&D & Antibiotics

While antibiotics help skin infections like cellulitis, they often can't fully treat an infection once an abscess has formed — which is why the I&D is necessary. Young, healthy, non-immunocompromised patients don't need antibiotics after an I&D of a small abscess <2 cm.

Most others need systemic antibiotics: deep abscesses (e.g., abdomen), multiple abscesses, significant surrounding cellulitis, or size >2 cm. But these antibiotics likely won't work without also performing the I&D.
MRSA-covering antibiotics
Cover for MRSAmost abscesses
Most abscesses are caused by Staphylococcus aureus and other gram-positives, but MRSA is very common, so standard cellulitis agents like Keflex may not work. MRSA-covering PO options:
  • Bactrim 1–2 tabs BID × 10 days
  • Doxycycline 100 mg BID × 10 days
  • Minocycline 100 mg BID × 10 days
  • Clindamycin 300 mg q6–8h × 10 days
  • Linezolid 600 mg BID × 10 days (expensive)
Perirectal and severe coverage
Perirectal & Severe Infectionsbroaden coverage
Drained perirectal abscesses need added gram-negative and anaerobic coverage: add Augmentin to a MRSA agent, or add Levaquin and Flagyl, or add Cipro to clindamycin. Severe infections requiring admission start on IV vancomycin ± Cipro/Flagyl or Zosyn. Send aerobic and anaerobic cultures to guide therapy.

Bacterial Endocarditis Prophylaxis

Certain at-risk patients should get oral antibiotic prophylaxis 1 hour before the I&D.

Who needs prophylaxis
Who Needs It
Prosthetic heart valves, rheumatic heart disease, unrepaired congenital heart disease, history of infective endocarditis, or central lines.
Prophylaxis options
Options
Bactrim; doxycycline and amoxicillin; minocycline and amoxicillin; or clindamycin — given 1 hour prior to the procedure.

Equipment

An I&D is invasive but is considered a clean procedure — you don't strictly need sterile gloves or a sterile field, though some still use sterile technique. Many facilities have pre-assembled kits.

I&D kit
I&D Kit
#11 scalpel, Betadine or CHG, 4×4 gauze, curved hemostats, scissors.
PPE
PPE
Clean or sterile gloves, gown, and a face shield (trust me — pus gushes).
Anesthetic
Anesthetic
1–2% lidocaine, 3–5 cc syringe, blunt needle, 25–30g needle.
Irrigation and packing
Irrigation, Packing & Cultures
Saline + splash guard/IV catheter for irrigation; iodoform or plain gauze packing tape, ABD pad, gauze, tape; aerobic and anaerobic culture swabs.

Prep & Anesthetize

Explain the procedure (a consent form may be required by facility protocol), position the patient comfortably with easy access to the abscess, raise the bed, and set up your equipment. Larger abscesses can be very painful — IV or IM morphine 4 mg or Dilaudid 1 mg may help if needed.

Why abscesses are hard to numb: they're an acidic environment, so lidocaine doesn't work as well as usual. Draw up 1–2% lidocaine with a blunt needle, switch to a 25–30g needle, and prime it. Give it 3–7 minutes to fully take effect with an abscess.
Linear block
Linear Blocksmaller abscesses <5 cm
Locally infiltrate lidocaine in a line where the incision will be, across the whole length of the abscess (this is painful). Make incisions along low-tension skin lines to reduce scarring. Inject just under the epidermis into subcutaneous tissue — not deep enough to enter the abscess itself — repeating along the projected cut line. Wait 3–5 minutes before incising.
Field block
Field Blocklarger abscesses >5 cm
Use the linear block plus a ring/field block — inject a ring of subcutaneous 1% lidocaine around the abscess, about 1 cm peripheral to the erythematous border. Max lidocaine dose is 4.5 mg/kg (max 300 mg); for 1% (10 mg/mL) that's ~30 mL in most adults >65 kg — you shouldn't come close.

Tips to Decrease Lidocaine Pain

Buffer the lidocaine 9:1 with 8.4% bicarb, use a smaller needle, inject slowly, use room-temperature lidocaine, stimulate adjacent skin, and use the ring/field block technique.

Field block anesthesia technique around an abscess
Field block — a ring of lidocaine around the abscess.

Make the Incision

Once the lidocaine has worked (3–5 minutes), make a linear incision with the scalpel — deep enough to penetrate the abscess wall but not so deep as to cause injury. Keep 4×4 gauze in your other hand, since purulent fluid usually gushes out immediately.

Cut the Full Length

Incise the entire length of the abscess — too small an incision is one of the main causes of a recurrent abscess.

Making a linear incision into an abscess
A linear incision across the full length of the abscess.

Obtain Cultures, Break Loculations & Irrigate

Young, healthy patients with abscesses <2 cm who won't get antibiotics don't need cultures.

Obtain aerobic and anaerobic cultures in patients started on antibiotics who have: significant cellulitis, systemic symptoms (fevers), recurrent abscesses, failure of initial antibiotics, very young or old age, or immunocompromise.
1
Break Up Loculations

Abscesses often become loculated — separate pockets of pus. Insert a hemostat into the incision and open it in all directions to break up loculations (this is often painful).

2
Irrigate the Incision

Draw sterile saline into a 20–60 cc syringe, attach a splash guard or IV catheter, and irrigate to clean out the abscess. Best practice, though not always done for smaller abscesses.

Breaking up loculations within an abscess with a hemostat
Breaking up loculations with a hemostat.

Pack the Wound (Optional)

I&D incisions are almost never sutured closed — they're left open to heal by secondary intention (naturally). Packing inserts special gauze that promotes drainage.

Packing is generally recommended for: abscesses >5 cm, pilonidal abscesses, and immunocompromised/diabetic patients.

Don't Over-Pack

Packing too tightly increases pressure and can cause tissue damage. Gently insert iodoform ribbon with a blunt object (like a cotton swab) — don't "stuff" it — and leave a 1 cm tail outside the wound. Cover with an absorbable dressing. Packed patients return for a wound check in 2 days; more packing can be placed if drainage continues.

Packing an abscess wound with iodoform ribbon gauze
Gently packing the wound with iodoform ribbon.

Discharge Instructions

Before discharge, confirm the patient's tetanus is up to date.

I&D without packing
Without Packing
Soak in warm soapy water 2–3 times per day; follow up in 7–10 days, or sooner if systemic signs of infection appear.
I&D with packing
With Packing
Return in 24–48 hours. Once packing is removed and drainage stops, begin warm soapy soaks.

Clinical Pearls

1
No fluctuance, no I&D. If you can't feel fluid under the skin, a trial of PO antibiotics is usually appropriate instead.
2
Drainage beats antibiotics alone. Antibiotics rarely clear an established abscess — and when needed, they must cover MRSA (Bactrim, doxy, clinda).
3
Cut the whole length and break loculations. An incision that's too small is the leading cause of recurrence.
4
Refer the risky ones. Perirectal, facial-center, breast, hand, and >5 cm abscesses belong to a surgeon — and wear a face shield.

References

Clinical Databases & Guidelines
  1. Downey KA, Becker T. Techniques for skin abscess drainage. UpToDate.
  2. Approach to management of drainable abscess or skin infection with purulent drainage in adults. UpToDate.
  3. Sexton DJ, Chu VH. Antimicrobial prophylaxis for the prevention of bacterial endocarditis. UpToDate.
Textbook
  1. Buttaravoli P, Leffler S. Cutaneous Abscess or Pustule. In Minor Emergencies. 3rd ed, pp. 655–659. Saunders, 2012.
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