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10 IV Insertion Tips for Nurses

William Kelly, MSN, FNP-C
Updated June 2026 · Medically reviewed for nurses
10 min read

IV insertion is a skill almost every nurse needs — used every day to infuse fluids and medications and to draw blood. It can be tough, especially for the new or inexperienced nurse, but with time and these 10 tips you'll sink those IVs like a pro.

1. IV Insertion: Location, Location, Location!

The best spot for your IV depends on your setting and the patient's chief complaint. Each site has clear trade-offs.

Cubital fossa
Cubital Fossa (AC)
An ER nurse's best friend. For neuro, cardiac, or pulmonary complaints that may get a CTA, choose the AC — radiology usually won't inject high-pressure dye without at least an 18g or 20g in a large vein. Hemodynamically unstable patients should get a 16–18g AC for resuscitation.
Forearm
Forearm
Perfect for continuous fluids since it won't kink with arm bending. Not everyone has good forearm options, and these veins don't always give reliable blood return.
Hand
Hand
Often the easiest veins to see, but small — an 18g may be tough. Great for short periods, but easily irritated, limit hand use, and hurt more with vasocaustic infusions like vancomycin or potassium.
Diagram of anterior arm veins used for IV insertion
Anterior arm veins commonly used for IV insertion.

Occlusion Alarm Tip

If a patient on continuous infusions keeps setting off the occlusion alarm with an AC line, ask if you can place another IV — preferably in the forearm or hand.

2. Small Veins? Make Them Larger

When the veins you've got are small, a few simple techniques can plump them up before you stick.

Heat
Heat
Causes vasodilation. A warm compress or hot pack makes the vein easier to see, palpate, and thread — just don't make it hot enough to cause thermal burns.
Gravity
Gravity
A dependent (lowered) arm pools blood in the distal veins, enlarging them and raising your chance of success.
Nitroglycerin ointment
Nitroglycerin Ointment 2%
A small amount applied topically dilates peripheral veins. In a small study, 2% nitro on the dorsum of the hand reduced needle sticks. It's a medication — you need an order.

3. IV Insertion with Fragile Veins

Some patients — often the elderly — have veins you can see fine, but that blow the instant you stick them, even with a 22g. Two adjustments help.

Change your selection
Change Your Selection
Look for larger, more proximal veins. IVs in these tend to be more stable and less likely to blow immediately.
Forget the tourniquet
Forget the Tourniquet
If you can see or palpate the vein without one, go without — tourniquets add pressure that fragile veins blow under. And never forget to remove the tourniquet before flushing.

4. Don't Give Up During the IV Insertion

Some nurses hate "digging," and that's understandable — but it's often minimally painful, and you can thread the catheter within seconds. The trick is to not dig blindly: use your fingers to palpate the accurate direction of the vein.

If you don't get a flash after inserting, pull the needle and catheter back to almost out of the skin, re-palpate, and aim again in the vein's direction. Plenty of IVs miss on the first pass but thread on the 2nd or 3rd advancement — and the patient's pain receptors desensitize, so it's usually less painful than a fresh poke. That said, some patients won't tolerate this and will tell you not to dig.

Never Re-Advance the Needle Alone

It is not recommended to retract only the needle while leaving the catheter in place and then re-advance the needle. This risks fracturing the catheter and leaving a foreign body in the patient.

5. Go Big or Go Home

Smaller is not always easier. Sometimes a 22g and below are too flimsy. When veins are sclerosed, hardened, or scarred, a 20g may thread more reliably — and 20g IVs are more durable and better in an emergency.

6. The Arterial Stick

When inserting an IV, you can accidentally hit an artery. The clues: the IV pulsates, blood fills the catheter very quickly (depending on MAP), and the blood is bright red rather than the darker red of venous blood.

Pulsating IV? Take It Out

"Access is access" doesn't apply here. Peripheral IVs in arteries have much higher complication rates — the worst being thrombophlebitis, and you can literally cause a blood clot in the patient's arm, especially if meds are infused. Remove the catheter and try again in an actual vein.

7. Inserting the IV "Outside the Box"

Think outside the lower arm. Look at the upper arm, where large veins sometimes sit close to the surface. Most facilities prefer an arm, but in a true emergency any access beats none.

The hierarchy when access is hard: lower-extremity veins are an option but carry high infection risk — avoid unless necessary. In a code, a temporary intraosseous (IO) catheter is preferred. If a good IV still can't be obtained, someone skilled with ultrasound-guided IV placement should try, or a PICC/central line should be considered.

8. Angle Danger

Many nurses and students miss purely on technique — they hold the skin taut, stabilize the vein, insert, and go right through it, unable to thread. The usual culprit is too steep an angle.

Aim near parallel to the skin (10–30°). Gliding in at this angle means that once you get a flash, the needle is likely still in the vein and the catheter can advance. Deeper veins may need a steeper angle. If you have a good flash but can't float the catheter, pull the needle and catheter back just a millimeter or two and try advancing the plastic catheter alone.

9. Rollie Pollie Ollie (Rolling Veins)

Some veins like to roll, and the patient will usually warn you. To minimize it:

Pick a stable vein
Pick a Stable Vein
Choose a larger, more proximal vein — these tend to be more stable and roll less.
Stabilize the vein
Stabilize the Vein
Hold the skin taut with your non-dominant hand to anchor the vein in place.
Keep muscles relaxed
Keep Muscles Relaxed
Tensed muscles move veins. Keep the patient relaxed — the comfort tip below helps.

10. Patient Comfort

This last tip is mostly about comfort. After cleaning the site, place the needle flush with the skin right where you'll poke, bevel up, and press it into the cleansed skin for 3–5 seconds before you poke. The longer you wait, the more the skin receptors desensitize — theoretically decreasing pain.

With less perceived pain, the patient is less likely to tense up, leading to a smoother, more successful placement.

Clinical Pearls

1
Match the site to the plan. CTA or unstable patient → large-bore AC; continuous fluids → forearm; short-term only → hand.
2
Go near-parallel. A 10–30° angle keeps the needle in the lumen so you can thread — too steep and you blow right through.
3
Pulsating, bright-red, fast-filling = artery. Pull it and re-stick a vein — arterial IVs risk clots and thrombophlebitis.
4
Never re-advance the needle into a seated catheter. It can fracture the catheter and embolize a foreign body.